Alginate Purification

High-quality alginates form strong gels and provide thick aqueous solutions. The purification methods offered by CD BioSciences all reduce the number of known contaminants in alginate, namely polyphenols, endotoxins, and proteins. An increase in the viscosity of the alginate solution was observed after alginate purification. Sodium alginate is the main alginate form. CD BioSciences provides production and purification of not only sodium alginate, but also alginic acid and calcium, ammonium and potassium salts, and propylene glycol alginate. Calcium alginate and alginic acid are obtained in the process of preparing calcium alginate from sodium alginate. Other salts are made by neutralizing moist alginic acid with a suitable base (usually ammonium hydroxide or potassium carbonate). The versatility and biocompatibility of alginates have led to the use of alginates as viscosity modifiers and stabilizers in food, cosmetic, and high-value medical applications, including wound dressings, drug delivery systems, and, more recently, tissues for regenerative therapy packages.

Fig. 1 Schematic presentation of alginate affinity purification (AAP). (A Chaudhari S, et al., 2015)

Our Services

CD BioSciences has a strong technical force and strict quality control, and the services' quality is stable and reliable. We ensure high-quality purification services through comprehensive internal management, from purchasing fresh natural seaweed to drying, crushing, preparation, purification, storage, and transportation. We also collect information on materials other than seaweed and evaluate, selecting raw materials according to appropriate criteria. Our services are listed as follows, but are not limited to:

• Alginic acid purification
• Sodium alginate purification
• Ammonium alginate purification
• Potassium alginate purification
• Lithium alginate purification
• Calcium alginate purification
• Magnesium alginate purification
• Propylene glycol alginate purification

Quality Control

In addition to improving purification methods, we have also established a quality management system. To achieve such difficult quality control, advanced analytical techniques with excellent accuracy, reproducibility, and specificity for alginate are required.

• Ensuring a hygienic manufacturing environment
• Employee hygiene management
• Quality control of raw seaweed
• Prevent microbial contamination and foreign body contamination
• Product inspection before shipment

Alginate Applications

• Bioengineering
  Bioengineering use alginate in different form and alginates are used as thermoresponsive and thermoreversible hydrogels in bioengineering.
• Antibacterial dressings
  Alginate dressings with additives, such as silver nanoparticles, charcoal, or other healthcare ingredients, have antibacterial, antifungal, and antiviral properties and reduce unpleasant odors.
• Pharmaceutical and medical uses
  Alginic acid is insoluble in water but swells in water. It is a better disintegrant than starch, so less amount is needed.

CD BioSciences is a professional service provider for the marine biology industry. Our extraction services of alginate can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Reference

• A Chaudhari S, R Kar J, S Singhal R. Immobilization of proteins in alginate: functional properties and applications[J]. Current Organic Chemistry, 2015, 19(17): 1732-1754.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).