Bacterial Infection

Overview

Epidemics and infectious diseases caused by bacteria are a serious health threat. However, antibiotic treatment has led to increasing bacterial resistance, and there is an urgent need to develop new therapeutic strategies to combat bacteria, including multi-drug-resistant bacteria. Since many safety and resistance issues are associated with synthetic chemicals, marine natural products (MNPs) with antimicrobial activity and good biocompatibility have a promising future in antimicrobial drug development. Compounds with antimicrobial activity such as fatty acids, acrylics, phenols, indoles, and other marine antibacterial drugs such as cephalosporins have been isolated from marine organisms. At CD BioSciences, our R&D team is dedicated to exploring marine resources to discover, isolate, and characterize new MNPs to accelerate the development of marine antimicrobial drugs.

Figure 1. Marine natural products and their synthetic analogs as promising antibiofilm agents for antibiotics discovery and development. (Deng Y, et al., 2022)

Advantages of MNPs

• Unique biological activity. MNPs can target specific pathogens for inhibition or killing, thus enhancing drug efficacy.
• Rich chemical structure. MNPs have diverse chemical structures, which can provide new chemical backbones and active groups for antimicrobial drug development.
• Lower drug resistance. Compared with traditional antibiotics, MNPs have lower drug resistance, which can extend the service life of the drugs.

What Can We Offer?

• Screening and Identification of MNPs

We utilize advanced screening techniques and identification methods to extract and isolate natural products with antimicrobial activity from marine organisms. Through collaboration with marine biologists, we collect samples from different aquatic habitats.

• Antimicrobial Activity Evaluation

Using advanced bioassay techniques, we were able to evaluate the antimicrobial activity of the screened MNPs, including in vitro bacterial inhibition assay, in vivo animal assay, etc., to assess their antimicrobial effects and safety.

• Optimization and Synthesis of Compound Structures

We employ cutting-edge techniques such as nuclear magnetic resonance, mass spectrometry, and X-ray crystallography to characterize the structure of compounds. For promising MNPs, we use synthetic biology to increase the yield of lead compounds and optimize their efficacy to improve their activity and reduce toxicity.

• New Drug Development

Based on the structural and active characteristics of MNPs, our technology platform carries out new drug discovery and development, including drug design, pharmacodynamic evaluation, and toxicology studies.

• Preclinical Research

We conduct clinical application studies of MNP antibacterial drugs through preclinical testing, demonstrating their effective antibacterial activity and favorable safety profile.

Reasons to Choose Us

• Abundant resource reserves. We are committed to researching marine resources, which provides a solid foundation for the screening and extraction of marine natural products.
• Strong technical support. Our team has rich experience in realizing the assessment of the antimicrobial activity of marine natural products to advance the research and development of marine drugs.
• Customized service. We will design solutions and provide customized services according to the different needs of our customers.

Related Services & Products

• Development of marine antibacterial drug
• Radicicol
• Questin
• Latrunculin B

As antibiotic resistance continues to pose a major threat to global health, the need for novel and effective antimicrobial drugs has strengthened. CD BioSciences has a specialized technology platform and extensive experience in unlocking the potential of marine natural products for the development of next-generation marine antimicrobial drugs. If you would like to learn more about our services, please feel free to contact us.

Reference

• Deng Y, Liu Y, Li J, et al. (2022). Marine natural products and their synthetic analogs as promising antibiofilm agents for antibiotics discovery and development[J]. European Journal of Medicinal Chemistry. 239: 114513.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).