Building of Zebrafish Model

Obesity is a disease involving excess body fat and a body mass index (BMI) > 30. Obesity is accompanied by many changes that cause the so-called metabolic syndrome, such as insulin resistance, liver fat, high blood pressure, heart problems and atherosclerosis. Abdominal fat accumulation is a key marker in obese patients because it is particularly associated with these metabolic and cardiovascular symptoms. Zebrafish share remarkable genetic, anatomical, and functional similarities with humans in terms of lipid metabolism, lipogenesis pathways, and the presence of all key organs required for lipid metabolism. This high degree of protection makes zebrafish a valuable model for understanding mechanisms of obesity and metabolic disease.

As a leading preclinical CRO in the field of metabolism using zebrafish, CD BioSciences provides obesity preclinical CRO services to help our clients accelerate the validation of their gene candidates. They can take advantage of our diet-induced adult and juvenile zebrafish models, which recapitulate key aspects of obesity and represent an efficient and cost-effective option for studying this condition.

Our Services

We specialize in building of zebrafish disease models for the early stages of drug discovery. You can take advantage of our ready-to-use models covering multiple research areas or request custom disease models in specific therapeutic areas. Our ready-to-use zebrafish disease models building services include:

• Epilepsy model building
• Parkinson disease model building
• Retinal degeneration model building
• Duchenne muscular dystrophy (DMD) model building
• Non-alcoholic fatty liver disease (NAFLD) model building
• Metabolic disorders and obesity model building

Zebra-System for Zebrafish Model Building

Our scientists have developed a complete zebra-system designed for the analysis of larval activity, movement patterns, and responses to external stimuli that can reveal information about stereotypic and epileptic behaviors, circadian rhythms, motor control, movement disorders, neurodevelopment, vision or Information changes in the auditory system. This research system is critical for scaling up zebrafish larval experiments:

• Traceability
• Reliability
• Reproducibility
• Accuracy
• Quality

Advantages of Our Zebrafish Model

• We provide zebrafish gene knockout service to construct different disease models.
• Our zebrafish modeling cycle is fast and affordable.
• The great flexibility of the CRISPR/Cas9 system allows the custom generation of zebrafish lineage models.
• High rate of success in knock-out generation (99%).

CD BioSciences is a professional service provider for the marine biology industry. Our zebrafish model building services can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).