Chemical Modifications of Alginate

Alginate, a polysaccharide extracted from seaweed, is abundant in resources and shows great potential in various industrial applications. However, alginates lack properties such as stability under aqueous conditions, and it is difficult to control the degradation rate of alginate-based materials, which is critical for various medical applications. Alginates have a large number of free hydroxyl and carboxyl groups distributed along the backbone of the polymer chain, therefore, unlike neutral polysaccharides, it has two types of functional groups that can be modified to alter properties compared to the parent compound. Therefore, researchers have modified alginates using physical or chemical methods to enhance physical properties, biocompatibility, and solubility, and also to control the biodegradability of alginate-based materials. Cross-linking using ionic, covalent, optical, and enzymatic methods is one of the preferred methods for altering the properties of alginates and their derivatives. In addition, the zwitterion-modified alginate can alleviate the foreign body reaction or cellular overgrowth caused by biomaterials, which can make alginate have a wide range of applications in biomedicine. CD BioSciences provides custom alginate modifications services to meet clients' needs.

Fig. 1 Design of zwitterionically modified alginates and their in vitro characterizations. (Liu Q, et al., 2019)

Our Services

After years of rapid development, CD BioSciences has a completely professional customer service's system, matching corresponding service support solutions according to customer needs. In order to obtain high-quality analytical results, CD BioSciences not only has expensive analytical instruments but also have well-trained staff with a proper understanding of the properties of alginates to design accurate modification methods while focusing on the actual properties. Our services are listed as follows, but are not limited to:

• Chemical Modification Services of the Hydroxyl Groups
• Oxidation
• Reductive-amination of oxidized alginate
• Sulfation
• Copolymerization
• Cyclodextrin-linked alginate
• Zwitterionically modified alginate
• Chemical Modification Services of the Carboxyl Groups
• Esterification
• Ugi reaction
• Amidation
• Fibrinogen-modified Sodium Alginate
  Fibrinogen-modified alginate can be used as a scaffold for skin tissue engineering. CD BioSciences provides alginate modification including:
• Sodium alginate
• Ammonium alginate
• Potassium alginate
• Lithium alginate

Our Advantages

• Collaborative expertise in global markets
• Mature service system
• Innovative sales and marketing strategies
• Regulatory and compliance
• Integrity values

CD BioSciences is a professional service provider for the marine biology industry. Our chemical modification services of alginate can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Reference

• Liu Q, Chiu A, Wang L H, et al. Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation[J]. Nature communications, 2019, 10(1): 1-14.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).