Development of Anti-tubercular Drug

Tuberculosis remains one of the greatest global health challenges of all time. Although current clinical use of first-line anti-TB drugs has reduced mortality, multidrug-resistant and extensively drug-resistant forms of the disease have now spread globally and become a global problem. Even so, few new clinically approved drugs have emerged in the past 30 years. Highly biodiverse marine organisms have received considerable attention in drug discovery over the past few decades, and emerging drug resistance in tuberculosis has stimulated interest in evaluating marine natural products (MNPs) for the treatment of this disease. Marine environments are a rich source of diverse compounds with intricate structures and potent biological activities. To date, more than 170 compounds with anti-tuberculosis properties have been isolated from marine organisms. These compounds, including alkaloids, peptides, terpenoids, and polyphenols, have demonstrated remarkable potential in inhibiting the growth and proliferation of Mycobacterium tuberculosis, the bacterium responsible for causing tuberculosis.

Our Services

Core analytical services are led by a team of dedicated, knowledgeable leaders with extensive analytical experience. Our focus on new technologies and continuous innovation enables us to provide customers with professional services in chiral separation, high-throughput purification, determination of physicochemical properties, isolation and identification of impurities.

• Prospecting and Collection
  We conduct comprehensive surveys and expeditions, exploring marine habitats worldwide to identify potential sources of anti-tubercular compounds.
• Extraction and Isolation of Marine-derived Compounds
  Our scientists utilize a range of extraction methods, including organic solvents, fractionation, and purification, to obtain pure and potent compounds for further analysis.
• Structure Elucidation and Optimization of Marine-derived Compounds
  We employ cutting-edge technologies, including nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and X-ray crystallography, to determine the structures of the bioactive compounds.
• Formulation and Drug Development of Marine-derived Compounds
  CD BioSciences possesses expertise in the formulation of anti-tubercular agents. Our team works on developing effective drug delivery systems that ensure optimal drug release and bioavailability.

Our Capabilities

• Milligram scale chiral and achiral separations.
• Large-scale chiral and achiral separations.
• Analytical services for regulatory-driven drug development, including monitoring and quality control of APIs, intermediates, raw materials, and finished products
• Separation and structure elucidation of API and drug product impurities.
• Natural product extraction, isolation, and structure elucidation

CD BioSciences is a professional service provider for the marine biology industry. Our marine anti-tubercular drug development services can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).