Diabetes

Overview

Diabetes is a metabolic disease with high blood sugar caused by insulin deficiency (type 1 diabetes) insulin resistance or insufficient secretion (type 2 diabetes). Due to its prevalence, high incidence, and high mortality, it has become the third largest threat to human health after cancer and cardiovascular and cerebrovascular diseases. Currently, long-term use of drugs for the treatment of diabetes has great side effects and cannot achieve the ultimate goal of controlling blood sugar. Therefore, the discovery and development of safer and more effective hypoglycemic drugs are of great significance for conquering diabetes. Marine natural products (MNPs) have anti-tumor, antiviral, antibacterial, anti-inflammatory, and hypoglycemic effects. They are an important source of new drug discovery and provide important materials for the screening and development of hypoglycemic drugs. CD BioSciences is committed to providing innovative biotechnology solutions, especially in the research and application of MNPs. We focus on the development of new anti-diabetic drugs and provide comprehensive services and support to global pharmaceutical companies and scientific research institutions.

Figure 1. Mechanisms of action for marine algal extracts and their bioactive compounds combating obesity and diabetes. (Magwaza S N, et al., 2023)

Classic MNPs and Hypoglycemic Activity

• Seaweed polysaccharides. Seaweed polysaccharides from brown algae, red algae, and green algae have significant hypoglycemic effects, can improve insulin sensitivity, promote insulin secretion, and inhibit intestinal absorption of sugar.
• Fucoxanthin. Fucoxanthin, mainly found in brown algae, lowers blood sugar by increasing insulin sensitivity and promoting lipolysis and has antioxidant and anti-inflammatory effects.
• Marine flavonoids. Flavonoids can exert hypoglycemic effects through multiple pathways, including enhancing insulin signaling, inhibiting α-glucosidase activity, and, reducing carbohydrate absorption.
• Marine peptides. Marine peptides extracted from marine fish and shellfish can regulate glucose metabolism, enhance insulin secretion, and protect pancreatic cells through antioxidant effects.

What Can We Offer?

• Screening of MNPs

We use high-throughput screening technology and advanced automated screening platforms to screen compounds with potential anti-diabetic activity from abundant marine biological resources.

• Compound Separation and Identification

We provide high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) nuclear magnetic resonance (NMR), and other technologies to separate and purify the screened active compounds to ensure high purity and accurate identification of the compounds.

• Activity Evaluation and Mechanism Research

Through in vitro cell experiments and in vivo animal models, we can systematically evaluate the hypoglycemic effect of compounds and deeply study their mechanism of action. We can provide a variety of cell lines and animal models, and through the combination of molecular biology and biochemical techniques, we can fully reveal the pharmacological effects and mechanisms of compounds.

• Structural Optimization and Synthesis

We optimize the structure of identified active compounds and use computer-aided drug design (CADD) to optimize the compound structure and further develop new anti-diabetic drugs with high efficiency and low toxicity.

• Pharmacology and Toxicology Research

Our platform is equipped with advanced pharmacology and toxicology research facilities to carry out systematic pharmacology and toxicology studies to evaluate the pharmacokinetics, pharmacodynamics, and safety of compounds.

• Preclinical Development

We have rich experience in preclinical research and a professional team, familiar with global drug regulatory requirements to ensure the smooth progress of the project.

Reasons to Choose Us

• Standardized process. We strictly follow drug development standards to ensure service quality and data reliability.
• Highly specialized. We have a team composed of professional chemistry and biology, which can provide a full range of services for our clients.
• Rich experience. We have been deeply involved in drug discovery and development for many years, providing efficient and innovative services to our clients.

Related Services & Products

• Development of Marine Antidiabetic Drug
• Fucoxanthin
• Methyl stearidonate

With the growing number of diabetes patients worldwide, the market demand for antidiabetic drugs is also expanding. CD BioSciences is leading the way in developing antidiabetic drugs with its strong and specialized R&D team. If you would like more information about our services or products, please contact us.

Reference

• Magwaza S N, Islam M S. 2023. Roles of marine macroalgae or seaweeds and their bioactive compounds in combating overweight, obesity and diabetes: A comprehensive review[J]. Marine Drugs. 21(4): 258.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).