Evaluation of Alginate Biological Properties

Alginate is a naturally occurring anionic polymer that has been extensively studied due to its biocompatibility, low toxicity, and relatively low cost of use in many biomedical applications. To date, alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications because these gels retain structural similarity to the extracellular matrix in tissues and can be manipulated to perform several key effects. Furthermore, each alginate production method is unique and requires tuning for its unique properties for practical application. At CD BioSciences, we are working to establish original analytical techniques suitable for evaluating the biological properties of alginate, while fully evaluating the validity of the test method itself. In addition to improving analysis, analytical techniques must be established to properly evaluate materials in the medical field, such as low-endotoxin alginates. To achieve such difficult quality control, advanced analytical techniques with excellent accuracy, reproducibility and specificity for alginate are required.

Fig. 1 Physical and biological properties of alginate/carbon nanofibers hydrogel films. (Llorens-Gámez M, et al., 2020)

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In the process of evaluating the properties of alginates, we have established analytical techniques that can properly evaluate materials in the medical field, such as low-endotoxin alginate analysis techniques. In order to obtain high-quality analytical results, we not only have expensive analytical instruments but also have well-trained staff with a proper understanding of the properties of alginates to design accurate evaluation methods while focusing on the actual properties.

• Antibacterial analysis of alginate
• Antifungal analysis of alginate
• Antiviral analysis of alginate
• Antioxidative analysis of alginate
• Anti-inflammatory analysis of alginate
• Anticancer analysis of alginate
• Biocompatible analysis of alginate
• Biodegradable analysis of alginate
• Non-toxic analysis of alginate
• Biocompatibility analysis of alginate
• Cytotoxicity assays and cell adhesion

Alginates Applications in Biomedical Fields

• Pharmaceutical applications
  Conventional roles of alginates in pharmacy include use as thickeners, gel formers, and stabilizers, as alginates can play an important role in controlled release pharmaceutical products.
• Delivery of small chemical drugs
  Alginate gels are typically nanoporous (with a pore size of about 5 nm), resulting in rapid diffusion of small molecules through the gel.
• Protein delivery
  Proteins can be incorporated into alginate-based formulations under relatively mild conditions, minimizing their denaturation.
• Wound dressings
  Alginate dressings minimize bacterial infection of the wound site.
• Cell culture
  Alginate gels can easily be used as 2-D or more physiologically relevant 3-D culture systems.

CD BioSciences is a professional service provider for the marine biology industry. Our evaluating the biological properties services of alginate can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Reference

• Llorens-Gámez M, Salesa B, Serrano-Aroca Á. Physical and biological properties of alginate/carbon nanofibers hydrogel films[J]. International journal of biological macromolecules, 2020, 151: 499-507.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).