Immunoassay Testing of Marine Polyether Toxins

The fate of polyether toxins in the aqueous phase, especially the bacterial biotransformation of toxins, is poorly understood. Polyether marine toxins are responsible for the phenomenon of seafood poisoning known as neurotoxic shellfish poisoning (due to brevistoxin), ciguatera (due to ciguatoxin), and diarrheal shellfish poisoning (due to okadaic acid). Using traditional techniques that combine haptens (pure toxins) with proteins to generate intact antigens, animal immunization, antibody isolation, and purification of specific antibody subpopulations, detectable brachytoxin, and ciguatoxin but not okadaic acid has been isolated distinguishing antibodies. Using microbial chemistry and purified toxins, a unique set of tools was created for studying the accumulation, purification, and site-specific localization of polyether ladder toxins in tissues, food sources, and clinical samples. At CD BioSciences, immunoassays play a central role in toxin detection by enabling sensitive and specific measurements of different toxins in complex biological marine polyethertoxin samples.

Our Services

We are well-versed in the knowledge required to develop and validate immunoassays in a regulated bioanalytical environment through our deep understanding of scientific, and statistical analysis needs. These attributes, combined with our comprehensive project management and availability to support high-throughput platforms and sophisticated methods in a compliant manner, make us well-positioned to meet all of your marine polyether toxins testing needs.

• Custom immunoassay development of polyether toxins
• Enzyme immunoassays (EIA)
• Liposome immunoassay (LIA)
• Enzyme-linked immunosorbent assays (ELISA)
• Fluorescence immunoassay (FIA)
• Chemiluminescence immunoassay (CLIA)
• Counting immunoassay (CIA)

Our Workflow of Immunoassay Testing

• Project management
  Our project managers act as the primary point of contact to ensure expectations are met, including timelines and costs.
• Method development
• Our method development team can help you determine the appropriate immunogenicity assay format to meet the drug tolerance needs of your bioanalytical project.
• Method validation
  Our analysis and method development teams work closely together to ensure a smooth transition from method development to method validation.
• Sample analysis
  With critical mass and MSD, ELISA, FL/CL, and Luminex platforms to meet your research needs, our macromolecule bioanalysis facility can perform high-throughput studies while meeting tight timelines.
• Sample management
  We have extensive experience in accelerating the processing of large numbers of samples

CD BioSciences is a professional service provider for the marine biology industry. Our immunoassay testing of marine polyether toxins can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).