Isolation of Marine Peptide Toxins

Marine biotoxins are one of the most rapidly developing fields of marine bioactive substances, and are also a hotspot in the research of new marine drugs. Among them, peptide toxins are the most toxic toxins. These marine peptide toxins specifically act on ion channels or subtypes of molecular receptors and they have specific physiological activities, such as analgesia, cardiotonic, antihypertensive, antiviral, anesthesia, etc. Therefore, marine peptide toxins have become an important source of clinical drugs. At the same time, as molecular probes, marine peptide toxins are also powerful tools in neuroscience to study the structure and function of ion channels or molecular receptor subtypes. The representative marine polypeptide toxins include sea anemone toxin, conotoxin, sea snake toxin, jellyfish toxin, spiny fish toxin, etc. Peptides extracted from marine sources have different functions and structures compared to peptides isolated from terrestrial sources. Most bioactive compounds isolated from marine environments are obtained from symbiotic microorganisms. Among these microorganisms, bacteria are an important source of peptide toxins, isolated by metagenomic studies from complex gene networks expressed under marine conditions.

Fig. 1 Distribution of peptides according to phylum and function. (Macedo M W F S, et al., 2021)

Our Services

Our vision is to be a trusted partner in the field of marine biotoxins to facilitate the application of peptide biotoxins in drug development. Using expertise in genomics, proteomics, and metagenomics, our scientists have been expanding the possibilities for isolating bioactive peptides. Our services are listed as follows, but are not limited to:

• Sea anemone toxin isolation
• Conotoxin isolation
• Sea snake toxin isolation
• Jellyfish toxin isolation
• Spiny fish toxin isolation
• Porifera peptide synthesis
• Cnidaria peptide synthesis
• Mollusca peptide synthesis
• Annelida peptide synthesis
• Arthropoda peptide synthesis
• Echinodermata peptide synthesis
• Chordata peptide synthesis

Our Sources of Peptide Toxins

At CD BioSciences, peptide toxins are isolated from fish, crustaceans, mollusks, algae, corals, sea anemones and cone snails.

Biological Activities of Peptide Toxins

Marine peptides toxins have broad-spectrum biological activities, such as antibacterial, antiviral, antioxidant, antihypertensive, cardioprotective, antiatherosclerotic, anticoagulant, immunomodulatory, antitumor, analgesic, antidiabetic, anxiolytic, neuroprotection and appetite suppression.

Applications of Peptide Toxins

• Cancer treatment
• Analgesic
• Skin toner
• Nutrient supplement
• Antihypertensive
• Anxiolytic
• Postprandial blood
• Glucose control
• Intestinal health

CD BioSciences is a professional service provider for the marine biology industry. Our isolation services of peptide toxins can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Reference

1. Macedo M W F S, Cunha N B, Carneiro J A, et al. Marine organisms as a rich source of biologically active peptides[J]. Frontiers in Marine Science, 2021: 889.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).