Thrombus

Overview

Thrombi are organized, hardened blood clots. Normal blood coagulation helps stop blood loss, such as when a minor cut or abrasion occurs. However, blood clots that form in arteries, veins, or the heart are a serious disease. Marine biological resources are one of Earth's most abundant natural resources, and marine drugs are widely used in the medical field. Anticoagulation is one of the important functions of marine natural products (MNPs), which prevent blood coagulation and thrombosis. CD BioSciences is committed to using these abundant marine active substances to promote the research and development of anticoagulant drugs and provide comprehensive solutions for the scientific community and pharmaceutical companies.

Classic MNPs and Anticoagulant Activity

• Seaweed polysaccharides. For example, fucoidan, which is mainly found in brown algae, has significant anticoagulant and antithrombotic effects. Studies have shown that fucoidan exerts its antithrombotic effect by inhibiting platelet aggregation and thrombin generation.
• Marine bioactive peptides. Bioactive peptides extracted from marine animals such as sea cucumbers and jellyfish have anticoagulant effects. For example, active peptides in sea cucumbers can inhibit platelet aggregation and reduce the risk of thrombosis.
• Chondroitin sulfate. Chondroitin sulfate extracted from shark cartilage shows anticoagulant and antiplatelet activity which can be used to prevent and treat thrombotic diseases.
• Carbadocin. Alkaloid compounds extracted from marine bacteria exert their antithrombotic effects by inhibiting coagulation factors.

What Can We Offer?

• Extraction and Separation of MNPs

By utilizing advanced extraction techniques such as supercritical fluid extraction, ultrasound-assisted extraction, etc., and separation techniques such as HPLC-MS and MS, we can extract and isolate biologically active natural products from a variety of marine organisms.

• Chemical Identification and Structural Elucidation

Our scientists use techniques such as nuclear magnetic resonance (NMR), MS, and X-ray crystallography to conduct detailed chemical identification and structural elucidation of the extracted natural products to ensure their purity and structural accuracy.

• Bioactivity Screening and Mechanism Studies

Through a series of in vitro and in vivo experiments, we evaluate the anticoagulant activity of natural products and conduct in-depth studies on their mechanisms of action.

• In vitro coagulation tests. Such as prothrombin time (PT), activated partial thromboplastin time (aPTT), etc.
• Antiplatelet aggregation test. We evaluate the inhibitory effect of natural products on platelet aggregation induced by ADP, collagen, etc.
• In vivo thrombosis model. We use mouse or rat models to study the antithrombotic effect of natural products in vivo.

• Drug Development Support

We provide customers with full support from early development to preclinical research.

• Medicinal chemistry optimization. Improve the efficacy and pharmacokinetic properties of natural products through structural modification and optimization.
• Pharmacology and toxicology evaluation. We will systematically evaluate the pharmacological and toxicological properties of natural products to ensure their safety and effectiveness.
• Formulation development. Our team develops suitable dosage forms and formulations to improve the stability and bioavailability of drugs.

Related Services & Products

• Development of Marine Anticoagulant Drug
• Development of Marine Cardiovascular Drug
• Development of Marine Antihyperlipidemic Drug

Reasons to Choose Us

• Advanced equipment and technology. Our platform has leading extraction, separation, identification, and bioactivity screening technologies.
• Highly professional. Our team is composed of experienced scientists with a strong background in drug development research.
• Customized. We provide tailored R&D services and solutions based on the different needs of our customers.

As a leading marine biotechnology company, CD BioSciences is committed to providing a full range of services, covering the extraction, separation, identification, and anti-thrombotic drug development of marine natural products. Our professional team has extensive experience and advanced technology platforms, which can efficiently transform marine natural products into potential drug candidates. If you would like more information about our services or products, please contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).