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Cardiovascular Disease Model
Overview
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. In the study of CVD, accurately simulating the development of the disease is essential for drug development. Zebrafish has become a valuable tool in cardiovascular research because the molecular mechanisms of blood vessel formation are similar to those observed in humans and other higher vertebrates. CD BioSciences has a rich background in marine biological research and advanced biotechnology, which can apply marine organism models to the study of cardiovascular disease, providing researchers with new research perspectives and solutions.
Why Choose Marine Organism Models?
- Rapid development. Zebrafish and Japanese medaka have a short heart development cycle, which allows the development and pathological process of the cardiovascular system to be observed in a short period.
- Transparency. Zebrafish embryos and larvae are transparent, which facilitates real-time observation of the development and functional changes of the cardiovascular system.
- High reproductive rate. It can quickly provide a large number of samples, which is conducive to large-scale screening and statistical analysis.
- Convenient genetic manipulation. Marine organisms are easy to edit genes, which facilitates the study of the effects of specific genes on cardiovascular disease.
Figure 1. Impaired cardiac and vascular development in light mutants. (Mittal N, et al., 2019)
Applications of Our Marine Organism Models in Cardiovascular Disease Research
- Cardiovascular Development Research
- Drug Screening and Evaluation
- Gene Function Research
- Toxicology Evaluation
- Biomarker Discovery
Our team uses marine organism models such as zebrafish and Japanese medaka to deeply study the development of the cardiovascular system. These models, due to their rapid development and transparency, allow us to use high-resolution imaging techniques to observe the development of the heart and vascular system in real time. Through gene editing technology, we can simulate various gene mutations, study their effects on the development of the cardiovascular system, and reveal the relevant molecular mechanisms.
Marine organisms, such as zebrafish and sea anemones, are often used for cardiovascular drug screening. Because their heart and vascular systems are similar to those of mammals, they can be used to evaluate the effects of drugs on cardiac function and potential side effects. We use high-throughput screening technology to help customers discover and evaluate potential cardiovascular drugs. Through systematic experimental design and advanced analytical methods, we evaluate the efficacy and safety of candidate drugs on the cardiovascular system and determine the optimal dose and treatment regimen.
Certain specific genes play a key role in the occurrence and development of cardiovascular diseases. We provide the most advanced gene editing technologies such as CRISPR/Cas9 to construct marine organism models with specific gene mutations and deeply study the functions of these genes. Through systematic physiological and pathological analysis of gene knockout or overexpression models, we reveal the mechanism of action of specific genes in cardiovascular diseases. This not only helps us understand the basic biology of the disease but also provides important clues for the discovery of new therapeutic targets.
Drug safety evaluation is an important part of the drug development process. We use marine organism models to conduct comprehensive toxicology evaluations to evaluate the toxicity and side effects of drugs on the cardiovascular system. These evaluations include not only acute and chronic toxicity studies of drugs but also carcinogenicity, mutagenicity, and reproductive toxicity evaluations of drugs. Our toxicology evaluation services ensure that customers can understand the safety of drugs in the early stages of drug development and provide guarantees for subsequent research.
By studying marine biological cardiovascular disease models, we can identify and validate new biomarkers. These biomarkers are essential for the early diagnosis and treatment of cardiovascular disease. For example, by using zebrafish models, we can further discover changes in specific protein or gene expression associated with heart disease, and these findings can be translated into clinical detection methods to improve the early diagnosis rate of the disease.
Reasons to Choose Us
- High efficiency. Our platform is configured with advanced equipment to ensure the accuracy and efficiency of the experiments.
- Professional team. We have experts in many fields who can provide specialized technical support and consulting services.
- Customized service. We provide design service processes according to the different needs of customers.
Related Services
CD BioSciences, a marine biology specialist, specializes in providing efficient and accurate biological model development services to support cardiovascular disease research for researchers worldwide. For more information about marine organism model services, please contact us.
Reference
- Mittal N, Yoon S H, Enomoto H, et al. (2019). Versican is crucial for the initiation of cardiovascular lumen development in medaka (Oryzias latipes)[J]. Scientific reports. 9(1): 9475.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).