Development of New Marine Proteins

Marine organisms are increasingly scrutinized due to their status as significant producers of bioactive peptides and enzymes. The majority of bioactive compounds derived from marine environments are procured from commensal microorganisms. Within this realm of microorganisms, bacteria hold paramount importance as a source of bioactive peptides, extracted from intricate gene networks expressed under marine conditions through metagenomic studies. A plethora of peptides have exhibited biotechnological prowess, encompassing antibacterial, antitumor, antihypertensive, anticoagulant, antifouling, and antioxidant activities, thereby rendering them valuable for employment in the pharmaceutical and food industries. Marine microbial enzymes manifest an extensive array of applications within the bioindustry. Microorganisms retrieved from extreme marine settings have yielded numerous enzymes, including amylases, caseinases, lipases, gelatinases, and DNases. These enzymes exhibit thermostability and the capacity to endure disparate pH ranges and other demanding conditions essential for industrial applications.

CD BioSciences is a marine biology company dedicated to bringing you best-in-class enzyme and peptide technologies. We use the most refined fermentation technology to develop highly efficient enzymes and peptides, providing reliable solutions for various industrial applications.

Fig 1. Current strategies for prospecting bioactive proteins from marine organisms. (Macedo M W F S, et al.,2021)

Our Services

Our bioprocess development and high-yield manufacturing processes can be designed to provide you with milligram or kilogram scale.

Novel Enzymes Development

• Marine Halophilic Enzyme Production
• Marine Microbial Lysozyme Production
• Marine Agarase Production
• Marine Cold-active Enzymes Production
• Marine Carrageenase Production
• Marine Xylanase Production
• Marine Chitinase Production
• Marine Collagenases Production

Novel Peptides Development

• Porifera Peptide Synthesis
• Cnidaria Peptide Synthesis
• Mollusca Peptide Synthesis
• Annelida Peptide Synthesis
• Arthropoda Peptide Synthesis
• Echinodermata Peptide Synthesis
• Chordata Peptide Synthesis

Quality Assurance

• AAA (amino acid analysis)
• NMR (nuclear magnetic resonance)
• Residual solvent determination
• Water determination
• Peptide content determination
• Stability testing
• Solubility testing
• Bacterial endotoxin determination

Timeline

• Fermentation optimization
  In order to increase the yield and stability of multiple parallel fermenters, we ensure that all fermentation processes are optimized.
• Final formulation and professional upscale
  We offer our customers the flexibility to choose the final formulation of the product, including: spray drying, lyophilization and fixation. In addition, we also have bioreactors from 1L to 1000L.
• Downstream processing and purification
  All of our products undergo downstream processing such as cell separation, homogenization, flocculation and centrifugation. Rigorous purification methods are then applied: centrifugation, microfiltration and ultrafiltration, chromatography and precipitation.

CD BioSciences is a professional service provider for the marine biology industry. Our development of marine proteins services can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Reference

• Macedo M W F S, Cunha N B, Carneiro J A, et al. Marine organisms as a rich source of biologically active peptides[J]. Frontiers in Marine Science, 2021, 8: 667764.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).