Hyperlipidemia

Overview

Hyperlipidemia is a condition in which plasma lipid levels are higher than normal due to abnormalities in fat metabolism, manifested by elevated serum total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), and decreased high-density lipoprotein cholesterol (HDL-C). With the increasing improvement of people's living standards, the incidence of hyperlipidemia shows a trend of increasing year by year and low age. Therefore, the development of safe and efficient lipid-lowering drugs has become an urgent need. Due to the special characteristics of the marine environment and the diversity of marine organisms, marine natural products (MNPs) contain many biologically active substances with novel chemical structures and specific biological activities, which are important for maintaining the ecological environment, and have gained a lot of achievements in lipid-lowering. CD BioSciences, as a professional marine biotechnology company, has always been committed to providing comprehensive and high-quality new drug development services for our customers. In the field of lipid-lowering drug development, we utilize the unique advantages of MNPs to provide professional technical support for our clients.

Figure 1. Mechanism via which omega-3 fatty acids lower triglycerides and the conversion of very-low-density lipoprotein (VLDL) into low-density lipoprotein (LDL). (Haque N, et al., 2022)

Classic MNPs and Lipid-lowering Ability

• Omega-3 fatty acids. EPA and DHA in Omega-3 fatty acids, mainly from deep-sea fish, can lower blood triglyceride levels, reduce low-density lipoprotein cholesterol, and raise high-density lipoprotein cholesterol, with anti-inflammatory and anti-thrombotic effects.
• Astaxanthin. Derived from marine algae, plankton, and seafood, astaxanthin is a potent antioxidant that can lower blood lipid levels by reducing oxidative stress and inflammatory responses and also improves lipid metabolism. In addition, studies have shown its potential to improve cardiovascular health.
• Fucoxanthin. Fucoxanthin has significant antioxidant and anti-inflammatory properties, which may inhibit adipocytosis and promote lipid metabolism, thereby lowering blood lipid levels.
• Chitosan. Chitosan is a naturally occurring polysaccharide compound that binds to fats and prevents their absorption, thereby lowering blood cholesterol levels.

What Can We Offer?

• Screening and Characterization of MNPs

With our specialized chemistry and biology team, we can screen compounds with hypolipidemic activity from marine natural products for the R&D needs of hypolipidemic drugs. We use advanced separation and purification technology, combined with biological activity evaluation, to identify the screened compounds and provide customers with marine natural products with hypolipidemic activity.

• Structure Optimization and Activity Evaluation

For the screened marine natural products, we use structural biology and pharmacology techniques to optimize the structure of the compounds and improve their hypolipidemic activity. At the same time, we use in vitro and in vivo models to evaluate the activity of the optimized compounds to ensure their hypolipidemic effects.

• Pharmaceutical Formulation Development

After obtaining marine natural products with hypolipidemic activity, we provide our clients with pharmaceutical formulation development services. By combining the nature of the drug, pharmacodynamic, and pharmacokinetic data, we will design a reasonable drug formulation to ensure the stability and bioavailability of the drug in the body.

• Data Analysis

We provide data collection, statistical analysis, and result interpretation services to ensure the accuracy and reliability of trial results. In addition, we also utilize professional data analysis technology to provide clients with in-depth mining and analysis of preclinical data to provide strong support for drug development.

Reasons to Choose Us

• Advanced technology platform. We have cutting-edge equipment and technology to efficiently accomplish compound screening, separation, and identification.
• Specialization. Our team consists of scientists and technologists with rich experience to ensure the efficiency and accuracy of the research.
• Comprehensive system. We provide a full range of services from initial research to preclinical development to meet the different needs of our customers.

Related Services & Products

• Development of marine antihyperlipidemic drug
• Development of Marine Cardiovascular Drug
• Astaxanthin
• Fucoxanthin

CD BioSciences is dedicated to helping our clients discover new lipid-lowering active compounds and successfully advance them to preclinical studies through natural products derived from marine microorganisms. If you are interested in our products or services, please contact us.

Reference

• Haque N, Parveen S, Tang T, et al. (2022). Marine natural products in clinical use[J]. Marine drugs. 20(8): 528.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).