Inflammation Model

Overview

Chronic inflammation includes dysregulated and maladaptive responses, including persistent inflammation, tissue destruction, and tissue repair failures, such as allergies, atherosclerosis, cancer, arthritis, and autoimmune diseases. Validated preclinical experimental models of inflammation are essential for further understanding chronic inflammatory diseases, from their pathophysiology to innovative treatment options. Currently, zebrafish has become a powerful animal model of inflammation because it provides the possibility of in vivo imaging and studying inflammatory responses early in life. CD BioSciences is committed to providing advanced marine organism model development services, helping customers accelerate scientific discovery and new drug development by leveraging the unique advantages of marine organisms, especially in the application of inflammation research. Our services cover a full range of support from model construction and experimental design to data analysis.

Marine organism models for inflammation research. Figure 1. Schematic overview of commonly used zebrafish larval inflammation models. (Xie Y, et al., 2021)

Applications of Our Marine Organism Models for Inflammation Research

Basic Immunology Research

Marine organism models provide a unique platform for studying the basic mechanisms of the immune system and revealing the basic principles of many human immune responses. We help researchers gain a deeper understanding of the types, functions, and interactions of immune cells by providing isolation, culture, and functional analysis services for marine biological immune cells. In addition, through gene editing technology, we can analyze immune signaling pathways in marine organism models, reveal the mechanism of action of signaling molecules, and provide solid data support for basic immunology research.

Autoimmune Disease Research

We provide autoimmune disease models based on marine organisms to simulate and study the occurrence of diseases. At the same time, through advanced detection technology, we monitor the immune response of marine organisms in autoimmune diseases, provide detailed data support, and use marine organism models to screen and verify candidate drugs for the treatment of autoimmune diseases, accelerating the development of new drugs.

Allergic Reaction Research

We construct marine biological allergic reaction models to simulate human reactions to various allergens and analyze the allergic reactions of marine organisms through a variety of experimental methods to reveal allergic mechanisms and potential therapeutic targets. In addition, we offer a high-throughput screening platform to evaluate the effectiveness of candidate anti-allergic drugs.

Chronic Inflammation Research

Marine organism models provide new tools and ideas for studying the pathological mechanisms and treatment strategies of chronic inflammation. We can construct a variety of marine biological chronic inflammation models, such as the zebrafish chemical inflammation model, to simulate the occurrence and development of inflammation and further reveal the mechanism of inflammation.

What Does Our Platform Support?

Model construction. We provide customers with high-quality marine biological model construction services. Including the entire process from species selection, and sample collection to laboratory cultivation.
Experimental design. We have an experienced team of scientists who can design customized experimental plans according to the research needs of customers. Using advanced technologies such as CRISPR/Cas9, we edit the genes of marine organisms to study the role of specific genes in inflammatory responses.
Data analysis. Our bioinformatics team provides comprehensive data analysis services, including genomic analysis, transcriptomic analysis, and proteomic analysis.

Related Services

As an expert in marine biology, CD BioSciences is committed to providing customers with a variety of model-building services and the most accurate data for the study of inflammation-related diseases, further assisting in drug development. For more information about marine organism model services, please contact us.

Reference

Xie Y, Meijer A H, Schaaf M J M. (2021). Modeling inflammation in zebrafish for the development of anti-inflammatory drugs[J]. Frontiers in cell and developmental biology. 8: 620984.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).