Metabolic Disease Model

Overview

Metabolic diseases such as type 2 diabetes and obesity caused by unhealthy lifestyles and metabolism have developed rapidly around the world and are becoming the main cause of death. Zebrafish as a model of type 2 diabetes has been used to study the mechanisms, treatments, and health management of diet induction, blood sugar levels, and insulin resistance. Using the zebrafish model, we can analyze the pathological phenomena and pathogenesis of diabetes at the whole animal level and conduct high-throughput drug screening. CD BioSciences is committed to providing high-quality biological model development services focused on metabolic disease research, helping researchers deeply understand metabolic disease mechanisms and accelerate drug development.

Marine organism models for metabolic disease research. Figure 1. 3D micro-CT analysis in normal fed and diet-included obese zebrafish. (Zang L, et al., 2018)

Advantages of Our Marine Organism Models

Unique physiological characteristics. Zebrafish embryos are transparent and easy to observe and manipulate; sea urchins have highly controllable development processes and are suitable for developmental biology research. In addition, they have special metabolic pathways that can provide unique insights when studying metabolic diseases.
Highly conserved genomes. The genomes of our marine organism models are highly conserved with humans, making them ideal models for studying human diseases. For example, zebrafish are an animal model with more than 85% genetic similarity with humans among vertebrates, which gives them unique advantages in gene function research.
Diversity. We offer a variety of marine organism models, including zebrafish, sea urchins, and certain types of shellfish. Each of these models has different advantages and is suitable for various types of metabolic disease research. Zebrafish are often used in cardiovascular disease and diabetes research, while sea urchins are outstanding in lipid metabolism and cell division research.

Applications of Our Marine Organism Models in Metabolic Disease Research

Diabetes

Zebrafish is considered a promising hyperglycemia model with a significant response to high glucose treatment, and its insulin response is useful for the study of anti-diabetic drugs. Through gene editing, we established a diabetes model in zebrafish to study its islet cell dysfunction and insulin resistance mechanisms. Our research can further reveal the role of multiple key genes in the pathological process of diabetes and provide an important basis for the development of diabetes treatment drugs.

Fatty Liver

We use gene editing technologies such as CRISPR/Cas9 to create zebrafish models with gene mutations associated with human fatty liver, such as mutations in genes such as PNPLA3 and TM6SF2, to study their role in fatty liver pathology. By comparing the responses of gene-mutant zebrafish and wild-type zebrafish under high-fat diet conditions, we can further analyze the effects of gene mutations on lipid metabolism and the development of fatty liver.

Lipid Metabolism Pathway

Sea urchins have unique lipid metabolism pathways and are an ideal model for studying lipid metabolism disorders. Our research team has revealed a variety of genes related to lipid metabolism through in-depth analysis of the sea urchin genome, providing a new perspective for the study of obesity and fatty liver. Through the sea urchin model, we have discovered some key regulatory factors and systematically analyzed the lipid metabolism pathway.

What Can We Provide?

Model Building

We provide complete marine organism model-building services, including gene editing and phenotypic analysis. Our team of experts ensures the high quality of the model and the reliability of the experimental data.

Gene Function Research

We use advanced gene editing technologies such as CRISPR/Cas9 to perform gene knockout or knock-in experiments in marine organisms to help customers study the function of specific genes in metabolic diseases. Our team has rich experience in gene editing and can complete complex gene operations efficiently and accurately.

Drug Screening and Evaluation

We have a high-throughput drug screening platform to evaluate the effectiveness and toxicity of drugs through marine organism models. Our screening platform can quickly and efficiently identify potential therapeutic candidates and conduct detailed efficacy and safety evaluations.

Data Analysis

Our team can use advanced bioinformatics tools to conduct in-depth analysis of experimental data and provide detailed research reports to help customers interpret the results and formulate the next research plan. The data analysis services we provide include gene expression analysis, metabolic pathway analysis, and system biology modeling to ensure that customers obtain comprehensive and in-depth research results.

Related Services

Marine organisms serve as new tools to advance the study of metabolic disease mechanisms and the development of new therapeutics. CD BioSciences is committed to providing marine modeling services to meet the needs of different researchers and to provide a full range of technical support. For more information about our services, please contact us.

Reference

Zang L, Maddison L A, Chen W. (2018). Zebrafish as a model for obesity and diabetes[J]. Frontiers in cell and developmental biology. 6: 91.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).