Neurodegenerative Disease Model

Overview

Neurodegenerative diseases are a class of diseases that cause cognitive or functional impairments due to the gradual loss or even death of neuronal structure or function, such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). These diseases have placed a huge burden on human health and society. Traditional disease models are often limited by their complexity and reproducibility. Marine organism models, with their unique physiological and genetic characteristics, provide new possibilities for studying neurodegenerative diseases. CD BioSciences provides marine organism model services for neurodegenerative diseases to better understand the pathological mechanisms of these complex diseases and develop effective treatments.

Marine organism models for neurodegenerative disease research. Figure 1. Schematic illustration of the monoaminergic localities and anatomy of the zebrafish brain. (Chia K, et al., 2022)

Advantages of Our Marine Organism Models

Marine organism models such as zebrafish, sea urchins, and marine mollusks have shown many unique advantages in the study of neurodegenerative diseases.

Unique nervous system structure. Marine organisms have diverse jumpy system structures, which are similar to the human nervous system in some aspects but have unique complexity.
Easy-to-operate genetic systems. Many marine organisms have efficient gene editing and expression systems, which facilitate gene function analysis and disease simulation.
Fast life cycle. Some marine organisms have a short life cycle, which can greatly shorten the experimental cycle and improve efficiency.

What Can We Offer?

CD BioSciences provides comprehensive marine organism model services, covering all stages from model construction to functional validation, to meet the diverse needs of neurodegenerative disease research.

Model Construction

We use modern gene editing technologies, such as CRISPR/Cas9, to construct marine organism models with specific gene mutations or gene knockouts to simulate the pathological characteristics of human neurodegenerative diseases.

Behavioral Analysis

Through high-resolution imaging and advanced behavioral analysis techniques, we further evaluate the model's motor function, learning and memory abilities, etc., to reveal the impact of neurodegenerative diseases on behavior.

Drug Screening

Using our efficient drug screening platform, we conduct large-scale compound screening to discover potential therapeutic drugs and evaluate their efficacy and toxicity in marine organism models.

Molecular and Cell Biology Analysis

We can use a variety of technologies, such as RNA sequencing, proteomics, immunohistochemistry, etc. to conduct in-depth molecular and cell biology analysis to explore the molecular mechanisms and signaling pathways of diseases.

Applications of Our Marine Organism Models in Neurodegenerative Disease Research

Alzheimer's Disease

By introducing mutations in the human APP and PSEN1 genes into zebrafish, we could mimic the pathological features of Alzheimer's disease, including the formation of Aβ plaques and cognitive dysfunction. This model has been used to screen a variety of potential drugs and revealed several key pathological pathways.

Parkinson's Disease

Using sea urchin and zebrafish models, we were able to construct mutants of various Parkinson's disease-related genes (such as LRRK2 and SNCA) and observed movement disorders and dopamine neuron degeneration similar to human disease. These models provide valuable resources for understanding the pathogenesis of Parkinson's disease and drug development.

Reasons to Choose Us

Specialty. We have a team of senior scientists and technologists with rich experience in the construction and analysis of marine organism models.
Advanced technology platform. We are equipped with the most advanced gene editing and molecular biology equipment to ensure accurate research results.
Customized service. We provide customized research solutions and comprehensive technical support according to client's specific needs.

Related Services

CD BioSciences, an expert in marine biology, has been committed to developing and applying cutting-edge organism models to advance research on neurodegenerative diseases. For more information about marine organism model services or to inquire about specific projects, please feel free to contact us.

Reference

Chia K, Klingseisen A, Sieger D, et al. (2022). Zebrafish as a model organism for neurodegenerative disease[J]. Frontiers in molecular neuroscience. 15: 940484.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).