Disease Simulation

Overview

In modern biomedical research, the selection of disease models is crucial for understanding disease mechanisms, screening drugs, and developing new therapies. The unique advantages and diversity of marine organism models make them an important resource for exploring new disease areas. CD BioSciences is committed to providing advanced tools for disease research, especially for modeling a wide range of diseases through marine organism models.

Figure 1. Effectiveness of zebrafish models in understanding human diseases. (Adhish M, et al., 2023)

Advantages of Marine Organism Models

• Gene Homology

In molecular biology, about 70% of zebrafish genes have functional similarities with humans, including some molecules in cell signaling pathways and genes involved in nervous system functions.

• Excellent Physiological Characteristics

Physiologically and genetically, some marine organisms such as zebrafish have similar digestive tracts, vascular systems, brains, immune systems, nervous systems, and transcriptional systems similar to humans.

• Environmental Adaptability

Many marine organisms can survive in extreme environments, such as high-pressure, low-temperature, and low-oxygen environments. The adaptation mechanisms of these organisms provide unique models for studying human diseases under similar extreme conditions, such as cardiovascular diseases and respiratory diseases.

Our Marine Organism Models for Disease Research

• Neurodegenerative Disease Model

We offer zebrafish and sea urchin models for the study of Alzheimer's disease and Huntington's disease. The zebrafish model allows us to study the mechanisms of neuronal degeneration and plaque formation, while the sea urchin model provides an ideal platform for studying synaptic function and neural circuitry through gene expression and protein aggregation studies.

• Cardiovascular Disease Model

Our zebrafish model can help study angiogenesis, blood pressure regulation, and cardiovascular drug screening, providing important data for hypertension research. In addition, the model allows us to study lipid metabolism, atherosclerosis formation, and inflammatory responses, providing new ideas for the treatment of atherosclerosis.

• Cancer Model

Zebrafish models are widely used in cancer research, especially in tumor formation, metastasis, and drug screening. We induce specific cancer genes in zebrafish through gene editing technology to observe the growth and development of tumors and test the effectiveness of anti-cancer drugs.

• Inflammation Model

Our sea urchin model provides a unique opportunity to study the regulation of inflammatory responses during regeneration. By studying the interaction between regeneration and inflammation, we can reveal the regulatory mechanisms of inflammation during regeneration and provide new ideas for regenerative medicine.

• Aging Model

Using a zebrafish model, our team has delved into the changes in mitochondrial function, apoptosis, and antioxidant defense mechanisms during aging. These studies shed light on the fundamental biological processes of aging and provide new targets for the development of anti-aging therapies.

• Metabolic Disease Model

We offer zebrafish models that are uniquely suited for insulin signaling, islet cell function, and glucose metabolism studies to help explore the pathological mechanisms of diabetes. In addition, our zebrafish models provide an effective platform for fat accumulation, metabolic syndrome, and appetite regulation, supporting obesity research and the development of therapeutics. With the non-alcoholic fatty liver disease (NAFLD) model, we can delve deeper into hepatic lipid metabolism, inflammation, and fibrosis, providing valuable data for NAFLD research and treatment.

Our Technology Platforms

• Gene editing technology
• Model Building
• Disease Simulation

Why Choose Us?

• Unique technology platform. We have a range of equipment and techniques for marine life model development and are committed to providing customized services.
• High efficiency. To accelerate the research process of our clients, we deliver results and data in a short period.
• Well-established confidentiality system. We follow a strict system to protect our client's data and information.

CD BioSciences can provide a wide range of marine models to support researchers around the world in making breakthroughs in the study of diseases and the development of new therapies. Our team is dedicated to providing our clients with model development services that help accelerate scientific discovery and medical advances. To learn more about our services, please contact us.

Reference

• Adhish M, Manjubala I. (2023). Effectiveness of zebrafish models in understanding human diseases—A review of models[J]. Heliyon.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).